Work

Photoinduced Difluoromethylation/Cyclization of 2-Aryl Indoles with HCF2SO2Na

Year: 2025

Type: article

Abstract: Difluoromethyl compounds are widely found in natural products, bioactive molecule and pharmaceuticals.A visible-light induced difluoromethylation/cyclization of 2-aryl indoles is described to construct indolo[2,1-a]isoquinolin-6(5H)-one derivatives using the inexpensive and easy-to-handle HCF2SO2Na as an HCF2 sources.Diverse difluoromethylated indolo[2,1-a]isoquinolines were readily obtained in moderate to good yields.Mechanistic studies demonstrate that the reaction may involve a radical process.

Source: Chinese Journal of Organic Chemistry

DOI: 10.6023/cjoc202409008

Authors: Jie Jiang, Jiali Li, Ruohan Pan, Yu Chen, Jiale Liu, Yucai Tang

Institution: Hunan University of Arts and Science

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: bronze

Funders: Hunan University, Scientific Research Foundation of Hunan Provincial Education Department

Award: G1969628117