Work

Nanoarchitectonics of a covalent organic supramolecular cage (COSC) for fluorescent visual detection of macrolides

Year: 2025

Type: article

Abstract: an aldol-amine condensation. Multiple hydrogen bonding sites were introduced into the building blocks to increase host-guest interactions. Meanwhile, by introducing a stimuli-sensitive module, TPE, the fluorescence of the supramolecule changes upon encapsulation of the clarithromycin guest which was a type of macrolides. The cage structure was fully characterized using NMR and high-resolution ESI mass spectrometry. The fluorescence recognition process and detection limitations of the cage for clarithromycin were investigated using NMR, UV-vis, and fluorescence spectroscopy. This study expands the application of precisely designed covalent supramolecular cages for monitoring antibiotic-based environmental pollutants.

Source: RSC Advances

DOI: 10.1039/d4ra09077b