Serum level of monocyte chemotactic protein 1, N-terminal brain natural peptide in patients with coronary heart disease after nutritional changes
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background: Coronary heart disease (CHD) is a leading cause of morbidity among elderly populations, with inflammation and cardiac dysfunction indicated by elevated MCP-1 and NT-proBNP levels. This study evaluated the effects of integrating Traditional Chinese Medicine (Baoyuan and Taohong Siwu decoctions) with standard Western therapy on serum MCP-1 and NT-proBNP in elderly CHD patients. Results demonstrated significant reductions in these biomarkers, supporting the complementary role of TCM in managing CHD. Methods: A total of 90 elderly CHD patients were randomly allocated into two groups (n=45 each): the control group (CG), receiving conventional Western medicine alone, and the research group (RG), treated with BYD-THSWD combined with standard Western pharmacotherapy. Serum levels of MCP-1 and NT-proBNP, lipid profiles (TG, TC, LDL-C, HDL-C), and clinical symptoms (chest pain, chest tightness, fatigue, sweating) were assessed at baseline and after 1, 2, and 3 months of treatment. Statistical comparisons between groups were conducted using independent-sample t-tests and chi-square tests. Results: After 3 months, serum levels of MCP-1 (113.09±5.49 vs. 126.38±7.04 pg/mL, P<0.05) and NT-proBNP (614.28±54.77 vs. 781.28±68.29 ng/mL, P<0.05) were significantly lower in the RG compared to the CG. Similarly, the RG exhibited significantly improved lipid profiles and greater symptomatic relief, reflected by significantly lower TCM symptom scores for chest pain, chest tightness, fatigue, and sweating compared to the CG at all post-treatment intervals (all P<0.05). Conclusions: Integrating Baoyuan decoction and Taohong Siwu decoction with conventional Western medicine significantly reduces MCP-1 and NT-proBNP levels, improves lipid metabolism, and alleviates clinical symptoms in elderly coronary heart disease patients. These findings highlight the potential of Traditional Chinese Medicine as a complementary therapy in enhancing standard CHD treatment outcomes.
Source: Journal of Medical Biochemistry
DOI: 10.5937/jomb0-55845
Authors: Yueyou Ding, Wenhui Ji, Hongchao Zheng, Zhancheng Wang
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410310874