Hemophagocytic Syndrome Secondary to Kikuchi–Fujimoto Disease: A Rare Case in a Pregnant Woman
Year: 2025
Type: article
Study design: Case Report
Abstract: Kikuchi–Fujimoto disease, also known as subacute necrotizing lymphadenitis, is a rare clinical self-limiting inflammatory disorder with unknown etiology. It typically manifests as fever, fatigue, and joint pain. The most common signs are lymphadenopathy, rash, and splenomegaly. In this rare case report, the patient was a woman in 10-week pregnancy with recurrent fever for 2 weeks. Her whole-body positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-d-glucose (18F-FDG) integrated with computed tomography revealed multiple enlarged lymph nodes throughout her body with increased 18F-FDG uptake. The patient was diagnosed with Kikuchi–Fujimoto disease based on the pathologic examination of the right axillary lymph node. Her bone marrow cytology indicated the presence of phagocytes and hemophagocytosis.
Source: Clinical nuclear medicine open.
Authors: Qianwei Li, Lianshan Zhan, Tian Tian, Xin He
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4410315208