Design, synthesis, and biological evaluation of novel N -(1 H -indazol-6-yl)benzenesulfonamide derivatives as potent PLK4 inhibitors
Year: 2025
Type: article
Abstract: PLK4 is a serine/threonine protein kinase situated at the centrosome, acting as a crucial regulatory element in the regulation of cell mitosis and significantly contributing to the preservation of genomic integrity.
Source: RSC Medicinal Chemistry
DOI: 10.1039/d5md00251f
Authors: Pengkun Sun, Cunzheng Fan, Nian Liu, Minghui Tong, Xuan Shi, Han Wang, Shuyi Mu, Ningyuan Hu, Yixiang Sun, Haoyu Zhang, Zixuan Gao, Dongmei Zhao, Maosheng Cheng
Institution: Shenyang Pharmaceutical University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4410325775