Work

Design, synthesis and biological evaluation of aryl chalcone derivatives of pyridine-benzoxazole-pyimidine-oxazole as anticancer agents

Year: 2025

Type: article

Abstract: A new library of aryl chalcone derivatives of pyridine-benzoxazole-pyimidine-oxazole ( 27a-j ) and their chemical structures were confirmed by analytical data. Further, all the newly synthesized compounds ( 27a-j ) were evaluated for their anticancer applications against human cancer cell lines by the MTT method. Here, the chemotherapeutic agent etoposide is used as a positive control. The obtained results were compared with etoposide. Most of the screened compounds displayed remarkable anticancer activity on all cell lines. Among them, five compounds exhibited more potent anticancer activity as compared to the positive control. Mainly, one compound, 27j, displayed superior activity on four cell lines. Furthermore, all the compounds displayed selective cytotoxicity against cancer cells but not against normal Vero cells (IC50 ≥19 μM), supporting the design method as a selective anticancer agents.

Source: Results in Chemistry

DOI: 10.1016/j.rechem.2025.102359

Authors: Abdulrhman Alsayari, S. Tasqeeruddin, Shaheen Sultana, Laxminarayana Eppakayala

Institution: King Khalid University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,870