Work

Traffic jam in lung capillaries: inter-organ communication impedes gas exchange after acute kidney injury

Year: 2025

Type: article

Abstract: Acute kidney injury (AKI) is a frequent complication in critically ill patients and triggers a systemic inflammatory response that can contribute to lung injury, ultimately worsening clinical outcomes. However, diagnostic and therapeutic strategies remain unavailable. In this issue of the JCI, Komaru et al. explored leukocyte trafficking and vascular pooling following AKI in mice as an underlying mechanism of acute lung injury. Using intravital microscopy, the authors observed rapid accumulation of neutrophils in pulmonary capillaries within minutes of AKI onset. These neutrophils followed monocytes and slowed blood flow. Notably, disruption of this process improved oxygenation. The findings provide insights into this complex inter-organ crosstalk and open avenues for future research.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci192917

Authors: Ulrich Matt, Susanne Herold

Institutions: Universitätsklinikum Gießen und Marburg, German Center for Infection Research, German Center for Lung Research, Cardio-Pulmonary Institute

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,200