Work

An AAV variant selected through NHP screens robustly transduces the brain and drives secreted protein expression in NHPs and mice

Year: 2025

Type: article

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.adr2531

Authors: Luis Tecedor, Yong Hong Chen, David E. Leib, Paul T. Ranum, Megan S. Keiser, Brian C. Lewandowski, Elli M. Carrell, Elena Lysenko, Icnelia Huerta-Ocampo, Sakshi Arora, Congsheng Cheng, Xueyuan Liu, Beverly L. Davidson

Institutions: Children's Hospital of Philadelphia, The Ohio State University, University of Pennsylvania

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W4410358252

FWCI: 6.622

Cites: 38

Cited by: 12

Related to: 10