Work

Polygenic and Polygene x Trauma Contributions to Alcohol Use and Problems Among Black Americans

Year: 2025

Type: preprint

Abstract: Aims To estimate polygenic and polygene x environment contributions to alcohol consumption and problems in the context of childhood maltreatment and lifetime trauma. Design Main and interaction effects models predicting alcohol consumption and problems were estimated using multiple linear regression. Covariates included age, sex, education, employment status, and ancestral principal components. Setting USA Participants A sample of 2,114 Black adults (75% female; M age =39.88, SD=13.92) recruited from the Grady Trauma Hospital in Atlanta, Georgia. Measurement Polygenic scores (PGS) for trauma-related symptoms (re-experiencing: PGS REEX , avoidance: PGS AVOID , hyperarousal: PGS HYPER , PTSD symptom score: PGS PCL ) and alcohol consumption (PGS AUDIT-C ) and use disorder (AUD; PGS AUD ) were derived using genome-wide association Million Veterans Program summary statistics with PRS-CS. Findings Childhood maltreatment and lifetime trauma (excluding childhood abuse) were positively associated with alcohol consumption (AUDIT-C) (β childhood-maltreatment =0.17, SE=0.02; β lifetime-trauma =0.28, SE=0.02) and alcohol problems (AUDIT-P) (β childhood-maltreatment =0.25, SE=0.02; β lifetime-trauma =0.27, SE=0.02). None of the PGSs were associated with AUDIT-C, but both the PGSs for re-experiencing (β=0.1, SE=0.03) and avoidance (β=0.08, SE=0.03) were positively associated with AUDIT-P. Experiencing lifetime trauma and being at elevated genetic risk for AUD (interaction-β Trauma_x_PGSAUD =0.17, SE=0.05) and hyperarousal (interaction-β TraumaxPGSHYPER =0.11, SE=0.06) were associated with higher AUDIT-P scores; while more lifetime trauma and higher genetic risk for AUD were associated with higher AUDIT-C scores (interaction-β Trauma_x_PGSAUD =0.12, SE=0.05). Conclusions Individuals with elevated genetic risk for AUD are more likely to consume alcohol and to develop worse alcohol problems in the context of lifetime trauma. Interventions focused on also minimizing the effects of trauma-exposure would be particularly beneficial among individuals at risk for AUD.

Source: medRxiv

DOI: 10.1101/2025.05.13.25327255