Effect of thymosin α1 on Immune response and organ function in acute aortic dissection surgery: PANDA II trial protocol
Year: 2025
Type: article
Study design: Study Protocol
Abstract: This multicenter randomized controlled trial evaluates the efficacy of thymosin alpha 1 (Tα1) supplementation in preventing organ dysfunction following acute type A aortic dissection (ATAAD) repair. Over 330 patients will be equally assigned to receive either Tα1 plus standard care or placebo with standard management. The primary endpoint involves calculating the difference in mean postoperative Sequential Organ Failure Assessment (SOFA) scores between groups, measured daily from postoperative days 7. By targeting post-operative immune system imbalance, this study aims to establish a novel therapeutic approach for reducing systemic inflammatory response syndrome (SIRS)-mediated organ injury and improving long-term outcomes in this high-risk population. Results will be disseminated through peer-reviewed publications and international conferences.Trial registration: ClinicalTrials.gov Registry (NCT05339529).
Source: Future Cardiology
Authors: Hong Liu, Si-Chong Qian, Ying-Yuan Zhang, Cheng-Bin Tang, Hong-Hua Yue, Guo-Liang Fan, Xin Zhao, Yi-Yao Jiang, Fu-Hua Huang, Zhi-Hua Zeng, Wei Wang, Xu-Ran Lu, Xiao-Kang Luo, Xiang-Feng Bai, Xiang-Xiang Zheng, Peng Xie, Chao Ma, Sheng Zhao, Hong-Jia Zhang, On the behalf of China Additive Anti-inflammatory Actions for Aortopathy and Arteriopathy (5A) and PANDA Trial Investigators
Institutions: Jiangsu Province Hospital, Capital Medical University, First Affiliated Hospital of Guangzhou Medical University, West China Hospital of Sichuan University, Tongji University, Qilu Hospital of Shandong University, First Affiliated Hospital of Bengbu Medical College, Nanjing Medical University, Second Affiliated Hospital of Nanchang University, Tianjin University, Xinjiang Medical University, Southern Medical University, First Affiliated Hospital of Kunming Medical University, Yili Friendship Hospital, Xiamen University, Soochow University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G8707723656
OpenAlex ID: W4410358342