Work

Stereological analysis of the naked mole-rat Heterocephalus glaber lung provides evidence of altered surfactant function and late alveolarization

Year: 2025

Type: article

Abstract: Naked mole-rats (NMRs) can adapt to hypoxic environments and are the longest-living rodents. Comparison of their lung structure with that of mice revealed that NMRs have a reduced alveolar surface area per body weight but an increased pool of intracellular surfactant. Additionally, the septa of NMRs were thicker with an occasional double-layered capillary network. These features indicate a high regenerative potential with late alveolarization and environmental adaptation, even in old animals (>18 years).

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00246.2024

Authors: Florian Geltinger, Susanne Holtze, Thomas Bernd Hildebrandt, Matthias Ochs, Christina Brandenberger

Institutions: Charité - Universitätsmedizin Berlin, Leibniz Institute for Zoo and Wildlife Research, Freie Universität Berlin, German Center for Lung Research, Medizinische Hochschule Hannover

Language: English

Topic: Neonatal Respiratory Health Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4410360868

FWCI:

Cites: 51

Cited by:

Related to: 10