Work

Genomes from a four-generation family reveal the rate of new mutations

Year: 2025

Type: article

Abstract: The rate at which mutations arise can be estimated by studying multigenerational human families. Reference genomes have been assembled for 28 people from four generations of the same family. This publicly available resource provides insight into the mechanisms that underlie mutations in the most complex regions of the genome. Mutations occur most often in repetitive genomic regions that are difficult to sequence and assemble.

Source: Nature

DOI: 10.1038/d41586-025-01474-5

Language: English

Topic: Genomics and Phylogenetic Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $12,690

OpenAlex ID: W4410369306

FWCI:

Cites: 5

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Related to: 10