Mechanisms of kudingcha tea in treating Parkinson's disease: a network pharmacology and molecular docking study
Year: 2025
Type: article
Abstract: Current PD treatment mainly relies on traditional symptomatic therapy, with new drugs having great potential. Kuding tea, a Chinese medicine with antioxidant properties, might treat PD via antioxidant-driven anti-aging, but its exact mechanism is unclear. This study, combining network pharmacology, differential analysis, PPI network, single-cell analysis, and molecular docking, identified 72 common targets (e.g., CCND1, BCL2L1, PARP1) related to apoptosis, oxidative stress, cell cycle regulation, and the JAK-STAT pathway. Molecular docking confirmed their potential roles, suggesting Kuding tea's components could influence these proteins and pathways, affecting oxidative stress, aging, and inflammation repair in PD treatment, and offering a new research direction for its therapeutic mechanism.
Author: <p>Haiyan Zhu<sup>1,2,3</sup>, Shenglong Mo<sup>2,3</sup>, Chongdong Jian<sup>2,3</sup></p>
Language: English
Subfield: Computational Theory and Mathematics
Field: Computer Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4410374081