Work

Copper-catalyzed asymmetric carbonylative hydroallylation of vinylarenes

Year: 2025

Type: article

Abstract: We describe a novel and efficient copper-catalyzed carbonylative hydroallylation of vinylarenes, providing a direct route to chiral α,β-unsaturated ketones, which are important compounds in organic synthesis and bioactive molecules. The method employs readily accessible vinylarenes and allylic phosphates, utilizing carbon monoxide as the carbonyl source under mild reaction conditions. The reaction demonstrates a broad substrate scope, including diverse vinylarenes with various functional groups, as well as vinylarenes derived from natural products. Additionally, all four stereoisomers of a chiral allylic alcohol were prepared by employing this strategy, showcasing its versatility in stereodivergent synthesis.

Source: Chemical Science

DOI: 10.1039/d5sc02421h

Authors: Sufang Shao, Yang Yuan, Alban Schmoll, Xiao-Feng Wu

Institutions: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Leibniz Institute for Catalysis, Dalian National Laboratory for Clean Energy, Nankai University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Natural Science Foundation of China, Chinese Academy of Sciences, National Key Research and Development Program of China

Awards: G3244092570, G4833463889, G8114047265