Work

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Year: 2025

Type: article

Abstract: The development of effective anticancer drugs remains a critical challenge despite significant advancements in technology and medicine. In this review, we explore the progress made in leveraging biomimetic microdevices for anticancer drug screening and their potential to enhance in vivo efficacy. Specifically, we discuss the utilization of innovative platforms such as xenograft models, patient‐derived xenografts, humanized immune system models, and transgenic models, alongside conventional multiwell plates, to mimic the tumor microenvironment and cellular interactions more accurately. Through the integration of advanced technologies, researchers have achieved remarkable improvements in drug screening, efficacy prediction, and identification of optimal drug combinations. This review provides insights into the strengths and limitations of these biomimetic microdevices compared to conventional multiwell plates, offering perspectives on their future role in personalized cancer medicine.

Source: Advanced NanoBiomed Research

DOI: 10.1002/anbr.202500060

Authors: Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee

Institutions: National Sun Yat-sen University, National Taiwan University

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,940