Work

Bromelain-Infused Poly(vinyl alcohol)/Hydroxyethyl Cellulose Nanofibrous Scaffolds for Cancer Therapy: Fabrication, Characterization, and In Vitro Assessment

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Nanofibrous scaffolds based on biomaterials have recently received a lot of attention due to their unique physicochemical characteristics. In this article, we disclose the encapsulation of bromelain in a poly(vinyl alcohol) (PVA)/hydroxyethyl cellulose (HEC) matrix to create a new type of nanofibrous scaffold. Bromelain has been used to impart new properties to PVA/HEC nanofibrous scaffolds, such as antibacterial, antioxidant, and biocompatibility. After examining the physicochemical properties of the nanofibrous scaffolds, it was discovered that bromelain was successfully incorporated into PVA/HEC nanofibers, providing a significant morphological structure to the scaffolds. The in vitro release study indicated that the loaded bromelain exhibited a sustained and controlled release behavior from the PVA/HEC nanofibrous scaffolds, thereby effectively inhibiting the growth of HeLa cells, as evidenced by microscopic observations. It should be emphasized that the PVA/HEC nanofibrous scaffold containing bromelain may have a promising application for cancer therapy.

Source: ACS Omega

DOI: 10.1021/acsomega.4c09347

Authors: Suganya Bharathi Balakrishnan, Lilian Ibrahim, Esakkimuthu Shanmugasundaram, Na’il Saleh, Stalin Thambusamy

Institutions: Dayananda Sagar University, United Arab Emirates University, Alagappa University

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,935