Work

Histamine is a molecular transducer of adaptation to endurance exercise training in humans

Year: 2025

Type: article

Abstract: Histamine appears to be intimately involved with skeletal muscle responses during and following exercise. Blocking histamine's actions during endurance exercise training by taking common over-the-counter antihistamines resulted in diminished gains in fitness. These results indicate that exercise-induced histamine release is important in generating many of the positive adaptations to exercise training.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00687.2024