Work

Photoredox Iron-Catalyzed Decarboxylative Radical Cyclization for the Synthesis of Oxindoles and Chroman-4-ones

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide A sustainable, photocatalytic approach for the synthesis of oxindoles and chroman-4-ones was developed using carboxylate salts as radical precursors and FeCl 3 as a catalyst. The reaction proceeds via a decarboxylative radical cyclization mechanism triggered by ligand-to-metal charge transfer under visible light irradiation, operating efficiently at room temperature. This method demonstrates excellent substrate scope, including the use of various alkyl carboxylates, and functional group tolerance and offers a scalable pathway for gram-scale synthesis, highlighting its practical application.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c00669

Authors: Shaoyang Han, Litao Liu, Jianqing Meng, Meichao Li, Qun Cao, Zhenlu Shen

Institutions: State Key Laboratory of Advanced Separation Membrane Materials, Zhejiang University of Technology, University of Leicester

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: UK Research and Innovation, National Natural Science Foundation of China, Engineering and Physical Sciences Research Council