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Modular access to functionalized azetidines via electrophilic azetidinylation

Year: 2025

Type: article

Abstract: Electrophilic azetidinylation reagents enable efficient, “any-stage” installation of azetidine rings onto nucleophiles, providing modular access to 3,3-disubstituted azetidines for drug development.

Source: Organic Chemistry Frontiers

DOI: 10.1039/d5qo00552c

Authors: Dayu Tian, Guang Chen, Xian Xiao, Xiaocheng Wang, Hai-Jun Zhang

Institution: University of Science and Technology of China

Language: English

Topic: Synthesis of β-Lactam Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Natural Science Foundation of China, University of Science and Technology of China

Awards: G2472733779, G6164533841, G7212303466

OpenAlex ID: W4410402194

FWCI: 3.197

Cites: 67

Cited by: 11

Related to: 10