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Propranolol is efficacious against Aspergillus and Fusarium corneal isolates in vitro and in a murine model of Aspergillus keratitis

Year: 2025
Type: article
Abstract: ABSTRACT Fungal keratitis is a severe corneal infection most commonly caused by filamentous fungi. Even with prompt treatment with current antifungals, it often results in corneal perforation and blindness. In this report, we observe that the beta-adrenergic antagonist, propranolol, displays antifungal activity against Aspergillus and Fusarium corneal isolates in vitr o and strikingly blocks disease establishment in a murine model of Aspergillus fumigatus keratitis. These findings suggest that beta-blockers have potential as a novel FK treatment. CLINICAL TRIALS This study is registered with ClinicalTrials.gov as NCT00997035 (MUTT Trial).
DOI: 10.1128/aac.01664-24
Authors: Michael E. Zegans, Manali M. Kamath, Jane T. Jones, Ruina Bao, Brandon S. Ross, Cecilia Gutierrez-Perez, Emily M. Adams, Jorge D. Lightfoot, Galini Poimenidou, Chetan Pavuluri, Venkatesh Prajna, Robert A. Cramer, Kevin K. Fuller
Institutions: Dartmouth College, Dartmouth–Hitchcock Medical Center, University of Pittsburgh, University of Oklahoma Health Sciences Center, Lawrence University, Aravind Eye Hospital
Language: English
Subfield: Ophthalmology
Field: Medicine
Open Access status: diamond
Funders: Cystic Fibrosis Foundation, Research to Prevent Blindness, National Institutes of Health, National Heart, Lung, and Blood Institute, National Eye Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases
Awards: G1228111781, G1775034595, G2489450958, G3031744635, G4139152366, G539529910, G6008557527, NEURAL CIRCUITS OF THE VISUAL THALAMUS, G9000342652, The Institute for Biomolecular Targeting, P30 Center Core Grant for Vision Research
OpenAlex ID: W4410403227
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Cites: 13
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Related to: 10