Multi-trait Analysis of GWAS Expands Eosinophilic Esophagitis Genetic Susceptibility and Polygenic Risk Scores
Year: 2025
Type: preprint
Study design: Observational Study
Source: Research Square
Authors: Michael P. Trimarchi, Bahram Namjou-Khales, Netali Ben-Baruch Morgenstern, Mark Rochman, Xiaoting Chen, Garrett Osswald, John Besse, Molly Shook, Julie Caldwell, Michael Lape, Tetsuo Shota, Matthew T. Weirauch, Melanie Ruffner, Gregory Constantine, Lisa J. Martin, Leah C. Kottyan, Marc E. Rothenberg
Language: English
Topic: Eosinophilic Esophagitis
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: American Partnership for Eosinophilic Disorders, Regeneron Pharmaceuticals, Rare Diseases Clinical Research Network, Eosinophilic Family Coalition, National Institutes of Health, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Advancing Translational Sciences, NHLBI Division of Intramural Research
Awards: G1213946416, CisBP and CisBP-RNA: web resources for protein-DNA and protein-RNA binding models, G2074485812, G2191075298, G2234417830, G241973223, G2542962027, G2914029385, G2976362549, Virus-driven human gene misregulation in disease, G4279768677, G4350553971, Role of TET1 in airway epithelium and childhood asthma, G481745248, G4913822037, G5070799704, G566358457, Genomics of Inflammatory Bowel Disease, Consortium of Food Allergy Research Clinical Research Center at Cincinnati Children's Hospital Medical Center (CoFAR-CRC:CCHMC), G6480079429, Polygenic Risk Scores for Healthier African American Families, G745487158, G8542680951, G9000029701, G9000034084, G9000042482, G9000055200, G9000082378, G9000112267, G9000116733, G9000159478, G9000169229, G9000185946, G9000199090, G9000297893, G9000318819, Cincinnati Rheumatic Diseases Resource Center, Molecular Mechanisms of the Dysregulated Immune Response to Ebola Virus, Data Management and Coordinating Center: Rare Diseases Clinical Research Network, Genetic and Immunological Dissection of Eosinophilic Esophagitis, G947216580
OpenAlex ID: W4410405178