Accuracy of Serum Neuron-specific Enolase (NSE) as a Predictor of Diagnosis in Colorectal Cancer Patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Aim: The aim of this study was to see in focus of the accuracy of serum NSE as a predictor of diagnosis in patient with colorectal cancer. Methods: The cross-sectional study evaluated the accuracy of serum NSE as colorectal cancer diagnostic predictor. Data were collected through for 9 months and consisted of two groups (control and CRC patient). Serum NSE was determined by enzyme lined immunosorbent assay (ELISA). Results: A total of 29 subjects were included in this study from each group (control and CRC patient). The mean age of each group were 53 years and 54 years old and predominantly male population in both groups. The predilection was found dominantly at the left colon (55.17%). The median of serum NSE of the CRC group (14,82 ng/ml) was significantly higher than that of the control (5,80 ng/ml). The area under the receiver operating characteristic curve (AUC) for NSE in CRC was 0,7759. Conclusion: Serum NSE has a good specificity and sensitivity that may represent as a tumor biomarker for diagnosing CRC in less invasive method. Keywords: colorectal cancer (CRC), neuron-specific enolase (NSE), tumor biomarker
Authors: Natassha Bianca, Taufik Sungkar, Masrul Lubis
Institution: Universitas Sumatera Utara
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410410444