Year: 2025
Type: article
Abstract: ABSTRACT Aging‐related retinal degeneration and vision loss have been severely affecting the elderly worldwide. Previously, we showed that the m 6 A reader YTHDF2 is a negative regulator for dendrite development and protection of retinal ganglion cells (RGC) in mice. Here, we further show that conditional ablation of Ythdf2 protects the retina from RGC dendrite shrinking and vision loss in aged mice. Additionally, we identify Hspa12a and Islr2 as the potential YTHDF2 target mRNAs mediating these effects. Together, our results indicate that the m 6 A reader YTHDF2 regulates retinal degeneration caused by aging, which might provide important therapeutic potential for developing new treatment approaches against aging‐related vision loss.
Source: Aging Cell
DOI: 10.1111/acel.70107
Authors: Fugui Niu, Gaoxin Long, Jian Zhang, Jun Yu, Sheng‐Jian Ji
Institution: Southern University of Science and Technology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,790
Awards: G1500487143, G587853106
OpenAlex ID: W4410411324