Oligometastatic Renal Ewing Sarcoma With FUS::ERG Fusion: A Case Report And Literature Review
Year: 2025
Type: article
Study design: Case Report
Abstract: Ewing sarcoma (ES) is an undifferentiated round cell sarcoma arising in skeletal and extraskeletal locations usually diagnosed in the second decade of life. It is typically characterized by a monomorphic round blue cell morphology, positive membranous CD99 immunohistochemical staining, and EWSR1 gene fusion with a partner gene from the ETS family. Less frequently, other genes from the FET family of genes substitute for EWSR1 . We report a case of oligometastatic Ewing sarcoma with FUS::ERG fusion with an unusual primary location in an older patient. This case highlights the application of ancillary tests, especially next generation sequencing, as an adjunct to the morphological assessment of undifferentiated round cell tumours. We also discuss potential diagnostic pitfalls and literature review of Ewing sarcomas with FUS::ERG fusion.
Source: Sage Open Pathology
Authors: Dan T. Nguyen, Trent Davidson, Fiona Maclean, Pranav Dorwal, Yeh Chen Lee, Min Ru Qiu
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4410411500