Work

Exploring N-heterocyclic linked novel hybrid chalcone derivatives: synthesis, characterization, evaluation of antidepressant activity, toxicity assessment, molecular docking, DFT and ADME study

Year: 2025

Type: article

Abstract: ][1,2,3]triazol-1-yl-based chalcone derivatives as promising antidepressant agents with a favorable safety profile. Density Functional Theory (DFT) analysis was performed on the most active compound, 13c, to gain insights into its structural and electronic properties. Additionally, ADME (Absorption, Distribution, Metabolism, and Excretion) profiling of the synthesized compounds indicated favorable drug-like characteristics and balanced pharmacokinetic profiles, supporting their potential as promising candidates for further pharmaceutical development.

Source: RSC Advances

DOI: 10.1039/d5ra01929j

Authors: Hemant S. Deshmukh, Vishnu A. Adole, Sanjay B. Wagh, Vijay M. Khedkar, Bapu S. Jagdale

Institutions: Loknete Vyankatrao Hiray Arts, Science and Commerce College, Savitribai Phule Pune University, Vishwakarma University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042