Work

Fabrication of Bioactive and Biodegradable Three-Dimensional Scaffold Based on Collagen Incorporated with Coenzyme Q10 to Enhance Full‑Thickness Wound Healing in Diabetic Rats

Year: 2025

Type: article

Abstract: In clinical settings, there is a need for novel wound healing methods to address full thickness wounds, particularly in individuals with diabetes. In this research, we investigated whether bioactive and biodegradable collagen-based scaffolds (CoSca) incorporated with coenzyme Q10 (CoQ10) could improve healing in diabetic rats. A total of sixty diabetic rats were randomly assigned to the control group, CoSca group, CoQ10 group, and CoSca+CoQ10 group. Sampling occurred on days 4, 8, and 12 for further assessments. Our results indicated that the speed of wound contraction, wound strength score, number of fibroblasts and blood vessels, collagen density, antioxidative factor levels (TAC and GPx), hydroxyproline levels, and concentration levels of TGF-β and VEGF were markedly greater in the treatment groups than in the control group, with these alterations being especially prominent in the CoSca+CoQ10 group ( p < 0.05). Meanwhile, the numbers of neutrophils, along with the concentration levels of TNF-α and IL-1β, as well as the levels of an oxidative factor (MDA), decreased more considerably in the CoSca+CoQ10 group when compared to the other groups ( p < 0.05). In summary, it was observed that the pairing of CoSca and CoQ10 greatly improves wound healing in diabetics.

Source: Bratislavské lekárske listy/Bratislava medical journal

DOI: 10.1007/s44411-025-00172-y

Authors: Mohammed A. Alshehri, Nahed S. Alharthi, Mohammed Alissa, Abdullah Alghamdi

Institution: Prince Sattam Bin Abdulaziz University

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,590