Year: 2025
Type: article
Study design: Case Report
Abstract: Introduction: Since 2011, nitrofurantoin has been reconsidered as a first-line treatment, but it can cause rare pulmonary and liver toxicity. Chronic use can lead to interstitial lung disease (ILD). The case presented highlights the suspicion of ILD in patients with respiratory symptoms after prolonged nitrofurantoin use. Case presentation: A 64-year-old woman receiving nitrofurantoin long-term developed severe pulmonary symptoms. After ruling out infections and autoimmune diseases, pulmonary toxicity was suspected. Treatment produced significant improvement, and she was discharged, continuing therapy and discontinuing nitrofurantoin. Conclusion: Nitrofurantoin toxicity is underreported in Mexico. Despite being safe, prolonged use can cause serious effects, so regular follow-up is essential.
Authors: Erick Jafet González Roblero, Karla Fabiola Aguirre avila, Erika Patricia Cerna Alcantar, Elizabeth Arellano Pacheco, Diana Karen Fernández López, Hannia Sarali Mares Cárdenas, Roberto Teutli Pérez, Jesús Arturo Portillo Ibarra, Mirtha Saavedra Vazquez
Institution: Mexican Social Security Institute
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4410415767