ANMCO position paper ‘Hypertrophic cardiomyopathy: from diagnosis to treatment’
Year: 2025
Type: article
Abstract: Hypertrophic cardiomyopathy (HCM) is a non-rare genetic cardiomyopathy, with an estimated prevalence of 1:500, characterized by an increase in the left ventricular wall thickness in the absence of increased loading conditions. The hypertrophy is mostly asymmetric and predominantly affects the basal septum and anterior wall. Left ventricular outflow tract obstruction, at rest or after provocative tests, is detected in many patients and represents the primary cause of reduced functional capacity, as well as an independent predictor of sudden cardiac death and advanced heart failure. Until ∼1 year ago, symptomatic patients despite maximal therapy with β-blockers or calcium channel blockers plus disopyramide had only basal septal reduction therapy through myectomy or septal alcoholization as additional therapeutic options. Today, a new class of drugs that inhibit cardiac myosin activity is available for patients with obstructive HCM. In light of the new treatment perspectives, the correct clinical-therapeutic classification of affected patients becomes of fundamental importance for the cardiologist. The aim of this position paper is to increase the knowledge of cardiologists in the field of HCM, defining its epidemiological, genetic, and pathological characteristics, identifying the diagnostic criteria and instrumental methods capable of stratifying the risk profile, with the aim of an optimal therapy tailored on the single patient.
Authors: Cristina Chimenti, Attilio Iacovoni, Andrea Montalto, Michele Emdin, Iacopo Olivotto, Cristina Basso, Benedetta Carla De Chiara, Irene Bottillo, Claudio Mario Ciampi, Santo Dellegrottaglie, Massimo Di Marco, Piero Gentile, Francesca Girolami, Paola Grammatico, Maria Iascone, Eluisa La Franca, Carla Lofiego, Andrea Matteucci, Daniele Pasqualucci, Samuele Pentiricci, Enrica Perugini, Maurizio Pieroni, Giovanni Quarta, Federica Re, Laura Scelsi, Giancarlo Todiere, Maria Alfarano, Monica De Gaspari, Claudio Bilato, Marco Corda, Leonardo De Luca, Giovanna Geraci, Massimo Milli, Alessandro Navazio, Vittorio Pascale, Carmine Riccio, Pietro Scicchitano, Emanuele Tizzani, Michele Massimo Gulizia, Federico Nardi, Domenico Gabrielli, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva
Institutions: Policlinico Umberto I, Sapienza University of Rome, Ospedale Papa Giovanni XXIII, Fondazione Toscana Gabriele Monasterio, Meyer Children's Hospital, University of Padua, Azienda Ospedale - Università Padova, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Azienda Ospedaliera San Camillo-Forlanini, Ospedale Garibaldi, University of Milano-Bicocca, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Azienda Ospedaliero-Universitaria delle Marche, ASL Roma, Ospedale San Filippo Neri, Azienda Ospedaliera G. Brotzu, Ospedale Maggiore Carlo Alberto Pizzardi, Azienda Ospedaliero-Universitaria Careggi, Policlinico San Matteo Fondazione, Azienda ULSS 8 Berica, Nuovo Ospedale San Giovanni di Dio, Azienda Usl Toscana Centro, Azienda Sanitaria Unità Locale di Reggio Emilia, Santa Maria Nuova Hospital, Ospedale degli Infermi, Azienda Sanitaria Locale Alessandria, HCF Fondazione ANMCO per il Tuo cuore ETS, Ospedale Generale Regionale Francesco Miulli, Associazione Nazionale Medici Cardiologi Ospedalieri
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4410416394