A wave of Thetis cells imparts tolerance to food antigens early in life
Year: 2025
Type: article
Abstract: In the intestine, peripherally induced regulatory T (pT reg ) cells play an essential role in suppressing inflammatory responses to food proteins. However, the identity of the antigen-presenting cells that instruct food-specific pT reg cells is poorly understood. We found that a subset of Thetis cells, TC IV, is required for food-specific pT reg cell differentiation. TC IV were almost exclusively present within mesenteric lymph nodes, suggesting that their presence underlies the phenomenon of oral tolerance. A wave of TC IV differentiation in the periweaning period was associated with a window of opportunity for enhanced pT reg cell generation in response to food antigens. Our findings indicate that TC IV may represent a therapeutic target for the treatment of food-associated allergic and inflammatory diseases.
Source: Science
Authors: Vanja Cabric, Yollanda Franco Parisotto, Tyler Park, Blossom Akagbosu, Zihan Zhao, Yun Lo, Gayathri Shibu, Logan Fisher, Yoselin A. Paucar Iza, Christina Leslie, Chrysothemis C. Brown
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4410419419