Work

Synthesis of Pyrrolidin‐3‐Ones and Spiropyrrolidinones by 1,3‐Dipolar Cycloadditions of Nitrones with Allenylphosphonates

Year: 2025

Type: article

Abstract: A general and effective (3 + 2) cycloaddition reaction between nitrones and allenes to synthesize fluoro‐phosphonopyrrolidin‐3‐ones, as well as spiropyrrolidin‐3‐one phosphonates is reported under microwave heating. The products have been isolated in moderate to good yields and exclusively as 4,5‐trans diastereoisomers in all transformations.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500390

Authors: Rayhane Hammami, Lucas Mele, Soufiane Touil, David Virieux, Jean‐François Poisson, Tahar Ayad, Benjamin Darses

Institutions: Centre National de la Recherche Scientifique, University of Carthage, Département de Chimie Moléculaire, Université Grenoble Alpes, École Nationale Supérieure de Chimie de Montpellier, Institut Charles Gerhardt Montpellier, Université de Montpellier

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funders: LABoratoires d’EXcellence ARCANE, Agence Nationale de la Recherche

Awards: CBH-EUR-GS, G2389725886

OpenAlex ID: W4410419647

FWCI: 1.171

Cites: 32

Cited by: 4

Related to: 10