Work

Antigenic and EM characterization of the Chiron experimental hepatitis C virus vaccine

Year: 2025

Type: article

Abstract: The Chiron experimental HCV vaccine, the only envelope-based HCV vaccine candidate to date, was immunogenic and safe in a phase 1 trial, though its efficacy remains untested. This study examined the antigenic properties of the vaccine antigens by immunoassays and EM, revealing inconsistent presentation of AR1/5 epitopes. The vaccine elicited mainly strain-specific neutralizing antibodies in humans and non-human primates, highlighting the need for rational antigen design to improve vaccine breadth.

Source: Vaccine

DOI: 10.1016/j.vaccine.2025.127239

Authors: Shr-Hau Hung, Jonathan L. Torres, Fang Chen, Erick Giang, Andrew B. Ward, Mansun Law

Institution: Scripps Research Institute

Language: English

Topic: Hepatitis C virus research

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,620