Work

Comparison of the Diagnostic Performance of the Central Vein Sign and CSF Oligoclonal Bands Supporting the Diagnosis of Multiple Sclerosis

Year: 2025

Type: article

Study design: Observational Study

Abstract: The central vein sign (CVS) describes the presence of venules within multiple sclerosis (MS) brain lesions, visible on T2*-weighted MRI. In the upcoming revision of the MS diagnostic criteria, the simplified “rule of 6” (i.e., finding 6 lesions with a central venule) can support the diagnosis of MS as an alternative to lumbar puncture (LP). We evaluated whether a T2*-weighted MRI scan is more sensitive than oligoclonal bands (OCBs) for diagnosing MS at presentation with a typical clinically isolated syndrome (CIS). We also compared the tolerability of LP and the additional MRI.

Source: Neurology Open Access

DOI: 10.1212/wn9.0000000000000017

Authors: Christopher Martin Allen, Margareta A. Clarke, Hari V. Pai, Marija Cauchi, Jonathan Hawken, Zin M. Htet, Kimberley Allen-Philbey, Bader Mohamed, Deborah Fitzsimmons, Roshan Das Nair, Paul Morgan, Christopher Partlett, Rob A. Dineen, Klaus Schmierer, Emma Clare Tallantyre, Nikos Evangelou

Institutions: University of Nottingham, Mater Dei Hospital, Cardiff University, Queen Mary University of London, Barts Health NHS Trust, Blizard Institute, Swansea University, SINTEF, Nottinghamshire Healthcare NHS Foundation Trust, Institute of Mental Health, Nottingham Biomedical Research Centre

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Institute for Health and Care Research

Award: DECISIve - DiagnosE using the Central veIn SIgn. A prospective diagnostic superiority study comparing T2* MRI and lumbar puncture in patients presenting with possible Multiple Sclerosis

OpenAlex ID: W4410425702

FWCI: 2.905

Cites: 30

Cited by: 5

Related to: 10