New insight on dietary strategies to increase insulin sensitivity and reduce diabetes prevalence: an expert perspective and recommendation
Year: 2025
Type: article
Abstract: This review investigates dietary strategies aimed at enhancing insulin sensitivity and reducing the risk of type 2 diabetes (T2D), with a special focus on recent meta-analysis evidence supporting the use of probiotics and synbiotics. Dietary interventions, such as the Mediterranean, low-carbohydrate, high-fiber, and plant-based diets, have shown significant promise in modulating glucose metabolism through mechanisms involving insulin receptor activation, glucagon-like peptide 1 (GLP-1) receptor signaling, and peroxisome proliferator–activated receptors (PPARs) regulation. Additionally, probiotics and synbiotics have emerged as complementary approaches, enhancing gut microbiota composition and improving insulin sensitivity through reduced inflammation and oxidative stress. The integration of molecular insights, including the role of siRNA and miRNA in gene regulation, highlights the potential for personalized nutritional therapies. This review provides evidence-based recommendations for daily dietary practices and suggests future research directions targeting combined dietary and molecular interventions for T2D management.
Source: Discover Food
Institutions: Sunan Kalijaga State Islamic University Yogyakarta, Universitas Airlangga, University of Indonesia, Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, Hasanuddin University, Udayana University, Badan Pengawas Obat dan Makanan, University of Naples Federico II, University of Bristol, Purdue University West Lafayette, Atma Jaya Catholic University of Indonesia
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,590
OpenAlex ID: W4410426273