Ultrasound-Responsive Mammalian Cell Synthetic Biology
Year: 2025
Type: article
Abstract: Sonogenetics is developing into a powerful tool in synthetic biology. The coupling of ultrasound (US) with genetically engineered effectors enables noninvasive and precise control of cellular and molecular processes. Building on established techniques such as optogenetics, it overcomes the limits of tissue penetration and invasiveness, making it a promising tool for both research and therapeutic applications. Recent advances in acoustic contrast agents, such as microbubbles and gas vesicles (GVs), have improved the mechanical effects of US on cells, extending its application to various biological systems. This review highlights recent advances and challenges, such as standardization of parameters and understanding of underlying mechanisms, and outlines future directions for US-guided cellular control.
Source: IEEE Transactions on Ultrasonics
Institution: National Institute of Chemistry
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Awards: G1747376282, G196196936, Ultrasound signaling cascade with calcium positive feedback loop as a signal amplifier for transient activation of chimeric antigen receptors for cancer immunotherapy, G3955162936, G4220831573, Synthetic biology and immunology, G4605518404, Sonogenetics - ultrasound modulation of target gene expression, Centre of Excellence for the Technologies of Gene and Cell Therapy, G773722777
OpenAlex ID: W4410428332