Year: 2025
Type: article
Study design: Observational Study
Abstract: Background. The prevalence of metabolic syndrome (MS) among people with type 1 diabetes mellitus (T1DM) varies widely depending on the criteria used and ranges from 6.4 to 57%. The relevance of studying the MS in T1DM is caused by the high risk of developing of micro and macrovascular complications. The current criteria for MS and the controversy over the inclusion of T1DM as a criterion do not provide reliability in diagnosing MS in this disease. The aim. To assess the prevalence of MS in adults with T1DM and its impact on the course of the disease. Materials and methods. A total of 134 patients over the age of 18 years were studied, including 67 (50%) men and 67 (50%) women. The median age was 33[19; 43] years, the median duration of diabetes was 13 [4; 27] years. MS was assessed according to the criteria of the 2009 Joint Interim Statement (JIS). Results. MS was detected in 34 (25.4%) patients. The number of patients who did not have other criteria for MS except for T1DM was 57 (42.5%), 43 (32.1%) patients had 2 components of MS (one of the components in all was diabetes). Waist circumference >94 cm in men and > 80 cm in women, as well as blood pressure > 130 and 85 mm Hg were the most common components of MS (73.5 and 70.6% respectively). The insulin sensitivity coefficient was significantly lower in the group of people with MS (p=0.012). In patients with MS, only diabetic nephropathy was significantly more common (p = 0.019), while the differences in the frequency of retinopathy and neuropathy were statistically insignificant. Conclusion. MS is a common condition in T1DM, which is based on insulin resistance. Presence of MS is associated with a risk of developing of diabetic nephropathy.
Source: FOCUS Endocrinology
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4410430530