Sensitizing solid tumors to CAR-mediated cytotoxicity by lipid nanoparticle delivery of synthetic antigens
Year: 2025
Type: article
Source: Nature Cancer
Authors: Lena Gamboa, Ali H. Zamat, Chloé A. Thiveaud, Hee Jun Lee, Elif Kulaksizoglu, Zizhen Zha, Noah S. Campbell, Ching Shen Chan, Sydney Fábrega, S. Abbey Oliver, Fang-Yi Su, Hathaichanok Phuengkham, Daryll Vanover, Hannah E. Peck, Anirudh Sivakumar, Shreyas N. Dahotre, Adrian M. Harris, Philip J. Santangelo, Gabriel A. Kwong
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, U.S. Department of Health and Human Services, Burroughs Wellcome Fund, Alfred P. Sloan Foundation, Georgia Institute of Technology, Emory University, Shurl and Kay Curci Foundation, Peking University, National Institutes of Health, Wallace H. Coulter Department of Biomedical Engineering, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering, Division of Electrical, Communications and Cyber Systems, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1015865649, G1057711716, G2035589694, G2444636963, G2491938545, G260816027, G2918871438, G3422421103, Graduate Research Fellowship Program (GRFP), G3824688650, G4414963549, G4529408795, G4950536974, G5004366791, Noninvasive and predictive biomarkers of organ transplant rejection, NNCI: Southeastern Nanotechnology Infrastructure Corridor (SENIC), G5927359219, G661928818, Breast Cancer Brain Metastasis Therapy by Focused Ultrasound-Guided Control of HER2 CAR T cells, IVIS Spectrum in vivo Imaging System, Focused ultrasound control of intratumoral NKG2DL BTE production by CART cells to potentiate epitope spread, G7094225672, G7126240543, G790860305, Graduate Training for Rationally Designed, Integrative Biomaterials - GT BioMAT, G9000004302, G9000029981, G9000055785, G9000316958, G9000333168, T32 CTEng (Cellular and Tissue Engineering) Training Program, Image-guided cancer therapy using heat activatable CAR T cells, Finding Sleeping Beauty: T Cell Biosensors for Dormant Cancer Detection
OpenAlex ID: W4410447679