Get started
Work

MONALISA: A Privacy-Preserving Infrastructure Supporting Liquid Biopsies to Monitor Relapsed Neuroblastoma

Year: 2025
Type: book-chapter
Abstract: The survival rate for high-risk neuroblastoma remains below 50%. Current monitoring methods are costly, invasive, and stressful for patients. MONALISA will evaluate liquid biopsies as a minimally invasive alternative, to enable frequent sampling and consequently early detection of genetic tumour markers. MONALISA leverages an advanced privacy-preserving data management infrastructure, including the SIOPEN BIOPORTAL, the EUPID Services, and patient reported outcome measures, providing a model for other paediatric cancers.
DOI: 10.3233/shti250462
Authors: Dieter Hayn, Emanuel Sandner, Bernhard Jammerbund, E. Sarper Okuyan, Jan Koster, Mandy M.J. Wittens, Godelieve A.M. Tytgat, Sabine Taschner-Mandl, Gudrun Schleiermacher
Institutions: AIT Austrian Institute of Technology GmbH, Amsterdam UMC Location University of Amsterdam, Cancer Center Amsterdam, Vrije Universiteit Brussel, IMEC, Princess Máxima Center, St. Anna Children's Cancer Research Institute, Institut Curie
Language: English
Subfield: Neurology
Field: Medicine
Open Access status: hybrid
OpenAlex ID: W4410447930
FWCI: 6.441
Cites:
Cited by: 1
Related to: 10