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Nasal primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma with fungal infection: A case report

Year: 2025

Type: article

Abstract: This report pertains to a case of nasal primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma, which was complicated by a fungal infection. The patient, a 66-year-old female, experienced pain in the left side of her face for 1 month. Pathological examination revealed the following: (1) primary systemic anaplastic lymphoma kinase-negative anaplastic large cell lymphoma. Immunohistochemical findings showed CD21(-), CD20 (clone L26) (-), CD3 (-), CD30 (+), Ki67 (60% +), CD5 (+), CD7 (-), CD56 (-), granzyme B (+), CK (-), CK5/6 (-), CD99 (+), Syn (-), S-100 (-), CD2 (+), CD4 (+), CD8 (-), CD43 (+), EMA (+), and anaplastic lymphoma kinase (5A4) (-). In situ hybridization results indicated EBER (-). (2) Microscopic findings suggested numerous fungal hyphae arranged in clusters or sheets, with PAS (+) and Grocott's methenamine silver stain (+) staining confirming the presence of a fungal infection.

Source: SAGE Open Medical Case Reports

DOI: 10.1177/2050313x251342938

Authors: Yun Huang, Liang Luo, Yi-bin Liu, Xin-Tao Wang, Long-Gui You, Huan Li

Institution: Ganzhou People's Hospital

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000