Year: 2025
Type: article
Abstract: Background: Proteins are crucial communicators in cells, converging signaling pathways through smooth interactions and modification that regulate cellular activity and responsiveness.Objective: The current research was conducted to examine how proteins engage with each other through protein-protein interactions (PPIs) and post-translational modifications (PTMs) and how their disruption results in human diseases. Methodology: Qualitative and integrative review of the literature was conducted utilizing peer-reviewed articles from the years 2015–2024, focusing on structural biology, proteomics, and disease models to investigate protein signaling mechanisms. Results: The study identified that PTMs and PPIs like phosphorylation, ubiquitination, acetylation, and methylation play critical roles in ensuring signal fidelity; their deregulation is implicated in cancers, neurodegenerative, and autoimmune diseases. Conclusion: Understanding protein communication language at the molecular level offers valuable insights into mechanisms of disease and a new door toward targeted therapeutic investigation.
DOI: 10.62019/b2y07688
Authors: Dr. Samiyah Tasleem, Faiza Akhtar, Muhammad Shahbaz Khan Afridi, Noor Ul Ain, Maria Aslam, Esha, Syed Husnain Raza Shah, Saadia Fayyaz, Muhammad Usama
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4410469378