Comparison of topical estrogen and platelet-rich plasma injections in the treatment of postmenopausal vaginal atrophy
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: Background: Platelet-rich plasma (PRP) is considered safe and is a low-cost, simple, natural, and minimally invasive method for vaginal rejuvenation. We aimed to compare the effects of hormonal treatment options and PRP use for postmenopausal vulvovaginal atrophy (VVA). Methods: From a total of 66 patients, topical estrogen treatment was administered to 36 patients, and PRP treatment was used on 30 patients who had previously received topical estrogen treatment without obtaining a response. To assess the impact of VVA and associated symptoms on the quality of life of patients, three different questionnaires, namely the Vaginal Health Index (VHI), Female Sexual Function Index (FSFI), and the Vulvovaginal Symptoms Questionnaire (VSQ), along with a Visual Analog Scale (VAS), were administered at 4-week intervals. Results: < 0.001, respectively). Conclusion: PRP injections are a safe and effective minimally invasive monotherapy for postmenopausal VVA and, consequently, vulvovaginal rejuvenation. PRP injections are regarded as a promising method for the treatment of VVA in postmenopausal patients with contraindications to hormone therapy and improving hydration of the vaginal mucosa.
Source: Frontiers in Medicine
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4410477299