Improved Catalyst System for Ag-mediated Liebeskind-Srogl Coupling of Tetrazine Thioethers with Arylboronic Acids
Year: 2025
Type: preprint
Abstract: An improved catalyst system, PdI₂/DiPPF, is described for the silver-mediated Liebeskind-Srogl coupling of thioalkyltetrazines with arylboronic and heteroarylboronic acids. The methodology advances the synthesis of functionalized tetrazines, offering greater efficiency, broader compatibility, and practical utility for accessing tool molecules for bioorthogonal chemistry applications.
Source: ChemRxiv
Authors: William Lambert, Stephanie Tsang, Ashlyn Hillman, Chuanqi Wang, Christopher am Ende, Joseph Fox
Institutions: University of Delaware, Pfizer (United States)
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Awards: Discovery of Chemical Probes and Therapeutic Leads, Phase II, Development of an Efficient 18F labeling technology based on tetrazine trans-cyclooctene ligation, G8414554082, High Sensitivity NMR Spectrometer with Cryoprobe, Delaware INBRE, Toolkit for Fast, Multipurpose and Inducible Bioorthogonal Chemistry, Q-Exactive Orbitrap LC-MC/MS System
OpenAlex ID: W4410477501