Work

Superacid-catalysed α-deuteration of ketones with D 2 O

Year: 2025

Type: article

Abstract: . The features of this catalytic process include simple manipulation, high deuteration efficiency (up to 99%), excellent functional group compatibility and a broad substrate scope, including 30 substrates comprising common building blocks and bioactive molecules like pentoxifylline. Moreover, the avoidance of toxic reagents enables sustainable access to deuterated products, demonstrating the method's practical potential for use in mechanistic studies and pharmaceutical applications.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d5ob00683j

Authors: Haiying Yuan, Kaibo Xu, Jinling Li, Teck-Peng Loh, Zhenguo Zhang, Zhenhua Jia

Institutions: Henan University of Technology, Nanyang Technological University

Language: English

Topic: Chemical Reactions and Isotopes

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: hybrid

Funders: Agency for Science, Technology and Research, Nanyang Technological University

Awards: G5575621636, G7002477465, G8054798955