0060 Exploring the Bidirectional Causal Associations Between Sleep Traits and Metabolomic Profile in Humans
Year: 2025
Type: conference-abstract
Abstract: Introduction Unhealthy sleep patterns are common phenomena which may lead to a spectrum of adverse cardiometabolic outcomes. Metabolites play pivotal roles in the relevant underlying mechanisms, yet the causal associations between sleep and metabolome in humans remain unclear. Methods This study applied one-sample Mendelian randomization (MR) to explore the relationship between sleep traits (sleep duration per day, short sleep duration (≤6 h), long sleep duration (≥9 h), and insomnia) and 249 metabolites among 166,436 participants from the UK Biobank. Single nucleotide polymorphisms identified in genome-wide association studies were used as instrumental variables. Initially, the two-stage least squares (2SLS) approach was performed to explore causality. Subsequently, inverse-variance weighted (IVW) and complemented methods were used as sensitivity analysis to further test the robustness of the results. Reverse MRs from each metabolites to sleep variables were also conducted. Results Genetically predicted insomnia was causally associated with level of most lipids and led to increased levels of acetoacetate (β2SLS [SE] = 0.173 [0.064]; βsensitivity-IVW [SE] = 0.039 [0.018]), glycoprotein acetyls (β2SLS [SE] = 0.768 [0.063]; βsensitivity-IVW [SE] = 0.111 [0.022]), and decreased levels of citrate (β2SLS [SE] = -0.155 [0.062]; βsensitivity-IVW [SE] = -0.058 [0.019]). Genetically predicted sleep duration was causally associated with increased average diameter for low density lipoprotein particles (β2SLS [SE] = 0.120 [0.032], βsensitivity-IVW [SE] = 0.106 [0.045]). Short sleep duration caused an increased the level of triglycerides in very low density lipoprotein subclass, apolipoprotein B to apolipoprotein A1 ratio and a decreased level of high density lipoprotein. We found no causal evidence for the effects of metabolites on any sleep variable. Conclusion Our study found that insomnia may lead to a wide range of metabolic disturbances, particularly in lipid metabolism, with short sleep similarly impacting lipid metabolic processes. This suggests that sleep traits may cause adverse outcomes through certain metabolic pathways. Support (if any) Rut and Arvid Wolff Memorial Foundation (X.T., 2023-02467), Åke Wiberg Foundation (X.T., M19-0266), Fredrik and Ingrid Thuring Foundation (X.T., 2019-00488)
Source: SLEEP
Author: Xiao Tan
Institution: Zhejiang University
Language: English
Topic: Sleep and related disorders
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $4,388
OpenAlex ID: W4410482342