Year: 2025
Type: article
Abstract: The mixture of concentrated nitric and sulfonic acids (mix acid) has been commonly used as a nitration reagent for the preparation of nitro compounds. Compared with the traditional batch reactor, continuous-flow nitrification technology has been recognized by the industry for its higher safety and production efficiency. As a frontier and hot topic in chemical engineering, continuous-flow reactor has gradually become an important platform for the development of new equipment, new processes, and new products for drug synthesis. Combining flow chemistry with real-time process analysis allows the study of reaction kinetics and the monitoring of the chemical synthesis process. In this work, the application of continuous-flow reaction technique in nitrification of aromatic rings, aromatic heterocycles, and aliphatic compounds is summarized. Based on process analysis technology and multistep series continuous-flow reaction to synthesize nitro compounds, the safe technology of nitrification reaction is realized in the green safety process.
Source: Pharmaceutical Fronts
DOI: 10.1055/a-2577-5738
Authors: Zhipeng Zheng, Xiaobing Liang, Xiaorong Zhou, Rui Zhu, Fengfan Liu
Institution: Zhejiang University of Technology
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4410486305