Work

A patient experiencing a decrease in heart rate during administration of intravenous ephedrine: A case report

Year: 2025

Type: article

Abstract: Ephedrine is a sympathomimetic agent with α1, β1, and β2 adrenergic-receptor effects inducing hypertension and tachycardia. It has direct post-synaptic adrenergic receptor agonism and indirect action by competitively inhibiting nor-adrenaline reuptake by synaptic vesicles at sympathetic nerve terminals, thus increasing its local concentration. We describe a case of a 35-year-old male, American Society of Anesthesiologists (ASA) physical status class II, undergoing right mastoidectomy for recurrent right post-auricular abscess, who developed repeated reduction in heart rate, each time after receiving an intravenous ephedrine bolus (6–9 mg/bolus). One of the possible reasons could be the simultaneous push of remifentanil during each bolus.

Source: JCA advances.

DOI: 10.1016/j.jcadva.2025.100129

Authors: Arunabha Karmakar, Muhammad Jaffar Khan, Navya Chetankumar Raval, Soudad Asim Shila

Institution: Hamad Medical Corporation

Language: English

Topic: Anesthesia and Sedative Agents

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,200