Work

Quantitative Trace Analysis of Dilute Mixtures Using a Benchtop NMR System with SABRE Hyperpolarization

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Despite their modest sensitivity, benchtop NMR spectrometers have recently attracted a great deal of attention, because of their low cost, high portability, and robustness. A solution to the sensitivity limitation of benchtop spectrometers is offered by nuclear spin hyperpolarization, by which large NMR signal enhancements can be realized. Signal Amplification By Reversible Exchange (SABRE) is one-such hyperpolarization technique, which utilizes hydrogen enriched in the para spin-isomer ( p H 2 ). However, the application of SABRE with benchtop NMR has so far largely been restricted to sample concentrations in the millimolar range. In this work, we present SABRE hyperpolarization of a mixture at micromolar concentrations, measured on a 1 T benchtop spectrometer. The observed linear dependence between hyperpolarized signals and concentration demonstrates the stability of our approach, which allows quantification in the micromolar range.

Source: Analytical Chemistry

DOI: 10.1021/acs.analchem.5c01026

Authors: Bono O. Jimmink, Mattia Negroni, Thom B. Posthumus, Arno P. M. Kentgens, Marco Tessari

Institution: Radboud University Nijmegen

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek, European Research Council