Work

Chitosan‐Polymer Conjugates as Functional Coatings for Liposomal Bioactive Delivery Systems

Year: 2025

Type: article

Abstract: Conventional liposomes hold promise as drug delivery systems but face challenges such as susceptibility to rapid clearance and limited targeting specificity. To address these limitations, polymer-coated liposomes have emerged as a viable solution, offering improved biocompatibility and targeted delivery capabilities. This study reports the synthesis and application of a chitosan-polyethylene glycol-folic acid (CTS-PEG-FA) conjugate as a functional liposome coating. The CTS-PEG-FA conjugate is synthesized and thoroughly characterized using spectroscopic techniques. Liposomes coated with this polymer are prepared via the thin-film hydration method and analyzed for particle size, zeta potential, and morphology through transmission electron microscopy. Using quercetin as a model drug, the system's drug-loading capacity and release kinetics are investigated. Results demonstrate that CTS-PEG-FA-coated liposomes facilitate enhanced cellular uptake and exhibit promising cytotoxic effects in cancer cells. This study highlights the potential of polymer-coated liposomes as a versatile and efficient platform for bioactive compound delivery with improved therapeutic performance.

Source: ChemMedChem

DOI: 10.1002/cmdc.202500191