BHLHE40-mediated upregulation of CAV1 decreases the radiosensitivity of nasopharyngeal carcinoma
Year: 2025
Type: article
Abstract: This study reveals that BHLHE40 reduces NPC radiosensitivity by transcriptionally activating CAV1, which in turn activates the Akt pathway. In addition, CAV1-containing exosomes secreted by radioresistant NPC cells promote angiogenesis, further accelerating tumor progression. These findings provide new insights into the molecular mechanisms of NPC radioresistance and suggest that targeting CAV1 could be a promising therapeutic strategy to enhance radiosensitivity and improve treatment outcomes.
Authors: Ying Bin, Lanhua Wu, Youchang Du, Xingyue Qiu, Yaoyi Huang, Min Kang, Li Jiang
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G3016274020, G4723507867, G8628765725
OpenAlex ID: W4410499804