A Comparative Study on Assessment of Empiric Antibiotic Susceptibility Rates between Traditional and Syndromic Antibiogram
Year: 2025
Type: article
Abstract: Backgroud Antibiogram serves as a crucial tool for providing guidance in empiric therapy. Most of the hospitals rely on Traditional Antibiograms (TA) for prescribing antibiotics. But recognizing the importance of Syndromic Antibiograms (SA) and integrating it into clinical practice enhances the effectiveness of empiric antibiotic therapy. It is crucial for the Antimicrobial Stewardship Programs (AMSPs) to extend their approach beyond the TA. Purpose: This prospective study was aimed to compare the susceptibility rates between a traditional and syndromic antibiogram for the most common organisms. Materials and Methods This study was conducted in a tertiary care hospital, Chennai for a period of 6 months. SA’s were developed and compared with TA to analyze the antibiotic susceptibility of the most common pathogens associated with Urinary Tract Infection (UTI), Respiratory Tract Infection (RTI) and Blood Stream Infection (BSI). The collected data were analyzed using SPSS version 23. Results A total of 400 bacterial isolates were examined. The three most frequently identified organisms were Escherichia coli (E. coli), streptococci and Salmonella typhi. The cumulative susceptibilities of these bacteria were compared using both TA and SA. A significant difference was found in the susceptibility rate of E. coli and streptococci species for fosfomycin, amikacin, nitrofurantoin, ampicillin and doxycycline between TA and SA. Conclusion Our study clearly depicted the variations in isolated microorganism’s susceptibility rate between a syndromic and traditional antibiogram. These differences may be significant, not only for selecting most effective empirical antimicrobial therapy for a patient but also helps in monitoring the resistance pattern of antibiotics to certain organisms within an institution.
Source: Journal of Young Pharmacists
DOI: 10.5530/jyp.20251540
Authors: Dhivya Kothandan, Sethumeena Singaram, Hanusha Venkatesan, Aswini Sankar, Shyam Sundar Subramanian, Lakshmi Priya Arul, Nandhani Nandagopal, Bala Abirami Mugunthan
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4410517676