Work

The price of WAR: AMR

Year: 2025

Type: article

Abstract: Background The ongoing conflict in Ukraine has exacerbated the risk of MDR bacterial infections in war-injured patients. Methods We present the case of a Ukrainian soldier who sustained a traumatic explosive injury to the bilateral lower extremities, underwent surgery and subsequently experienced an infection with a carbapenem-resistant Klebsiella pneumoniae. The isolate was subject to genomic WGS. Results This case study describes the successful management of a traumatic injury in a Ukrainian soldier infected with a carbapenem-resistant K. pneumoniae isolated from surgical wounds. WGS revealed a hypervirulent ST147 strain carrying multiple resistance and virulence factors, including blaNDM-1. Treatment with ceftazidime/avibactam and aztreonam was effective. Conclusions Ceftazidime/avibactam and aztreonam is highlighted as a promising regimen for MDR infections in conflict zones.

Source: JAC-Antimicrobial Resistance

DOI: 10.1093/jacamr/dlaf083

Authors: Laura J Rojas, Tracy L Lemonovich, Steven H Marshall, Adam Hirschfeld, Federico Perez, Robert A Bonomo

Institutions: Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, MetroHealth, MetroHealth Medical Center

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,609